Identification of the Blood-Group ABH-Active Glycoprotein Components of Human Erythrocyte Membrane
نویسندگان
چکیده
منابع مشابه
Chemical characterization and distribution of ABO blood group active glycoprotein in human erythrocyte membrane.
Occurrence and distribution of glycoprotein H substances in blood type O human erythrocyte membrance were studied using an alpha N-acetylgalactosaminyltransferase (A-enzyme) purified from milk of blood type A women. Erythrocytes of blood group O, nonsecretors and secretors alike, contain H substances that serve as a substrate for this transferase, and the H determinants seem to occur in all thr...
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More than ten new types of gangliosides, in addition to haematoside and sialosylparagloboside, were isolated from human erythrocyte membranes. These were separated by successive chromatographies on DEAE-Sephadex, on porous silica-gel columns and on thin-layer silica gel as acetylated compounds. Highly potent blood-group-Ii and moderate blood-group-H activities were demonstrated in some of the g...
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The Rh blood group proteins are well known as the erythrocyte targets of the potent antibody response that causes hemolytic disease of the newborn. These proteins have been described in molecular detail; however, little is known about their function. A transport function is suggested by their predicted structure and from phylogenetic analysis. To obtain evidence for a role in solute transport, ...
متن کاملIsolation and Characterization of a Glycoprotein from Human Group 0 Erythrocyte Membrane*
A glycoprotein was isolated from human group 0 erythrocyte membranes previously treated with detergents by a mild extraction with 90% phenol and further purified by successive passages through columns of DEAE-, CM-Sephadex, and Sephadex G-100 followed by a chloroform-methanol extraction. The purified glycoprotein appeared to be a single molecular species in gel filtration, polyacrylamide electr...
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Erythrocytes, which constitute more than 40% of the blood volume and about 3% of the body mass, are an important, although frequently neglected, detoxification organ. The main route of xenobiotic metabolism in erythrocytes goes through the glutathione conjugation process, and subsequently comprises removal of the conjugates via the membrane active transport systems. In human erythrocyte membran...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1980
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1980.tb04414.x